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Although promising cartilage regeneration was achieved with the treatment of the PTK hydrogel in this study, there are still several deficiencies we need to claim

This is potentially due to the formation of inhibitory fragments by brush-border enzymatic degradation of LA during the ex vivo recovery process

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In the case of another dipeptidyl peptidase, dipeptidyl peptidase IV (clan SC, family S9), in which a catalytic / hydrolase fold is covered by a regulatory -propeller domain, the N-terminus of the substrate is held precisely in position by strong interactions with the side chains of a double Glu motif (Glu205-Glu206) from an insertion helix of the regulatory -propeller domain 14,16 (Fig