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Its highest concentrations are found in the liver, the bodys central organ for detoxification, where it plays a vital part in neutralizing harmful free radicals, supporting phase I and phase II liver detoxification pathways, and helping to eliminate heavy metals and environmental toxins

Cancer treatment including chemotherapy, radiation, immunotherapy, endocrine therapy, and cold capping can adversely affect the constitution of patients

In plasma, it is released through enzymatic degradation of larger proteins, particularly SPARC (secreted protein acidic and rich in cysteine, also called osteonectin) and collagen

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