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Two FDA-approved alpha-2 agonists for hypertension treatment are methyldopa and clonidine, and dosages are dependent on the name and route

Hum Mutat 3:373378

Quantitative susceptibility mapping (QSM) shows increased regional brain iron that tracks amyloid-related cognitive decline in longitudinal cohorts (Ayton et al., 2017), with elevated hippocampal iron detectable in vivo by MRI (Raven et al., 2013)