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Zn deficiency impairs TGFR subtype 2 induction after retinoic acid in human cell lines (202)

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The stabilization of HIF is mediated by the inactivation of Prolyl 4-Hydroxylases (PHDs), allowing the rapid translocation of HIF to the nucleus where it forms a heterodimer with the HIF subunit, and induces the activation of genes with HREs in their promotors [111,112,113,114]