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All these results indicated that HMGB1 regulates oxidative stress induced by ferroptosis when exposed to high levels of glucose and that DN caused by ferroptosis can be alleviated by knocking out the HMGB1 gene

10.1017/cjn.2018.311 Can

In contrast, when employing the mutant form of ATG2A (ATG2A-mYFS), which does not interact with WIPI4 (Zheng et al, 2017), as a control, WIPI4 was found to be equally co-precipitated by both ATG2A and ATG2A-3CS (Fig