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Within this complex pathophysiological framework, a wide array of inflammatory cytokines and markers are involved, each playing an indispensable role and notably impacting the developmental trajectory of CHD

Figure 1 Wnt signaling is known to regulate a wide range of developmental processes such as body axis and segment polarity, mesoderm and endoderm differentiation, hair follicle and nephron development, and epithelial-mesenchymal transition (Logan and Nusse, 2004)

28 Another study showed that an aqueous extract of HEFB increased secretion of extracellular NGF and neurite outgrowth activity

Microglial depletion reduced CD3 + and CD8 + T cells and attenuated tau pathology in TE4 mice