glutathione reductase in caco-2 cells differentiated Apoptosis and glutathione: beyond an antioxidant Caco-2 [Caco2] - HTB-37 |

During the acute phase of the disease, but also several months or years after successful antibiotic therapy, a significant proportion of patients develop symptoms of hypothalamic-pituitary insufficiency (62)

Among these were DNA damage-inducible transcript 3 (DDIT3), also known as CHOP, and tumor necrosis factor receptor superfamily member 10B (TSFRSF10B), also known as DR5, which have been implicated in apoptotic pathways triggered by the unfolded protein response in the endoplasmic reticulum (ER) (Lam et al., 2020)

The absence of oxidative stress presumably prevented cell death under cystine or GSH depletion alone, suggesting that cysteine and GSH cooperate to mitigate oxidative stress

^ Felig P., Pozefsk T., Marlis E., Cahill G.F