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This protective action reduces reactive oxygen species (ROS) production, lowering oxidative stressa key contributor to cellular aging and mitochondrial dysfunction

Cet article a t crit avec le soutien et relu par Laurence Michel, chercheuse spcialiste de la dermatologie lInserm, David Boccara , professeur des universits-praticien hospitalier, chirurgien plasticien lhpital Saint-Louis (AP-HP) et chercheur associ lunit Inserm 976, et Armelle Rancillac , chercheuse en neurosciences lInserm et au Collge de France, spcialiste du sommeil et coordinatrice nationale de la Semaine du Cerveau

Evening administration fights against circadian suppression of p53, requiring higher effective concentrations to achieve the same apoptotic threshold in senescent cells