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The lower proportion of insulin triggers activation of glycogen synthase kinase-3 beta (GSK3B), a multifunctional serine/threonine protein kinase enzyme and ultimately produces hyperphosphorylation of Tau protein and accumulation of neurofibrillary tangles causing CD (Umegaki, 2010)

Berra, M., Liao, L

doi: 10.1038/nrgastro.2013.119

Recent advancements in nanodelivery systems, such as microneedle-assisted nanostructured lipid carriers, have enhanced localized drug delivery, showing significant inhibition of MDA-MB-231 cell migration and tumor growth in xenograft models [30]