does sam-e increase glutathione Excess S-adenosylmethionine inhibits methylation via catabolism to adenine S-Adenosylmethionine (SAMe) for Liver Health:

In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

Diabetes 63, 1219

Toxicol in Vitro 21: 12411246 Wong CH, Bozinovski S, Hertzog PJ, Hickey MJ, Crack PJ (2008) Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion

All this was shown in vivo with Histoplasma capsulatum fungal infections as well [263]