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Dual starvations induce pyroptosis for orthotopic pancreatic Cancer therapy through simultaneous deprivation of glucose and glutamine

These fatty acids then enter the mitochondria, where they are oxidized to generate energy

Front Immunol (2021) 12

Such a system is provided by glutathione reductase, which catalyzes the reduction of GSSG by NADPH, a product of the pentose phosphate pathway (Fig 5.27)