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A rigorous ethical framework is also essential: clear consent procedures, extensive long-term monitoring, and worldwide regulatory collaboration must be established before any responsible effort at heritable intervention

As we learn more about how it works, it could become an important tool for managing weight

In this study, we screened from an in-house developed metabolites library and identified MeCbl, an endogenous coenzyme form of vitamin B12, as a potent and specific inhibitor of GSDME without any effects on GSDMD