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GLUTATHIONE Glutathione is a powerful antioxidant

doi: 10.1074/jbc.RA118.003469 74 RabekJPBoylstonWH3rdPapaconstantinouJ

Diabetes, in turn, promotes inflammation and may increase B6 demand

Both intrinsic factors, properties arising in the malignant cells, such as MYC amplification, PIK3CA , and TP53 mutations, and extrinsic factors, metabolic stresses imposed by the microenvironment, such as hypoxia, oxidative stress, acidosis, contribute to different metabolic programming phenotypes in metastatic breast cancer