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GLP-1RA might also be valuable in knee osteoarthritis (KOA) amelioration, which represents the typical load-bearing complication of obesity and a leading cause of disability and reduced health-related quality of life

In the major obesity and diabetes trials, Tirzepatide was typically studied at 5 mg, 10 mg and 15 mg maintenance doses , with escalation from a lower starting dose over a period of weeks to improve tolerability

11 Vice versa, it is likely that if cytoprotective agents induce the innate counteraction of the initial Robert-lesions (alcohol, NSAIDs) in the stomach, the same agent exhibits an alike counteraction of the other lesions regularly induced by alcohol and NSAIDs (i.e., in liver, brain)

Functional instability involves neuromuscular deficits including impaired proprioception, delayed muscle reaction times, and poor motor control that persist even when mechanical structures appear intact