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In another study, nicotinic acid affected the hepatic uptake of ApoAI lipoprotein, thereby reducing high-density lipoprotein (HDL) removal from the circulation (reviewed in 20)

10.1038/nm1267 137

In animal models, ranging from invertebrates to non-human primates (NHP), studies have demonstrated that GAs have the capacity to inflict a range of temporary and permanent cognitive dysfunctions, as well as lasting structural impairments including increased cell death, suppressed neurite growth, and altered synapse formation (414)