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Pivotal research by Rudman and colleagues found that six months of GH in older men increased lean body mass and reduced fat mass versus placebo [7] , and long-term studies in adults with GH deficiency show sustained body-composition benefits with maintenance dosing [8]

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important for validating cross-species effects Humans Multiple Phase 1-3 trials in healthy volunteers and patients with sexual dysfunction Cell culture MC4R-expressing cell lines for receptor binding and signaling studies Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite FDA approval for a specific indication and extensive research over two decades, PT-141 faces several important limitations that restrict broader clinical application and understanding