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First a wide mask covering the peptide exit tunnel site was used for focused 3D classification, resulting in one class containing NMT1 and NAC in its canonical positions (8%) and one where NMT1 and NAC were observed in different positions (8%)

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In this section, we will discuss how different regulatory mechanisms modulate SLC7A11 expression or activity and downstream biological effects mediated by SLC7A11, with a focus on ferroptosis