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We were also able to activate JNK using C2-ceramide (Supplementary Fig

Glutathione is an abundant intracellular thiol (a compound containing a sulfhydryl group) and low molecular weight tripeptide found in living cells.* Serving as an antioxidant in all types of tissues, the antioxidant functions of glutathione include recycling vitamins C and E to their antioxidant form to minimize oxida

As NAC and GSH are thiol group (-SH)-containing antioxidants, apart from directly neutralizing ROS, they also provide precursors for endogenous GSH synthesis including cysteine, glutamine and glycine under the regulation of NRF2 (Nuclear Factor, Erythroid 2 like 2), the master gene regulator responding to cellular oxidative stress, and GCLC (Glutamate-cysteine ligase catalytic subunit), and the first rate-limited enzyme in cellular GSH biosynthesis [17, 18]

Prevention of PIN1-MAT1A interaction increases MAT1A levels in mitochondria and protects against alcohol-promoted mitochondrial malfunction and fat storage