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290,291,292 Accumulating macrophages release cytokines and chemokines, including IL-1, IL-6, chemokine ligand 2 (CCL2), and TNF-, intensifying the inflammatory environment and aggravating nerve damage

doi: 10.1007/s11010-023-04853-6

however, overexpression of both enzymes does not result in an increase in these esters (Saerens et al

[344] [345] [346] [347] Notes According to the British National Formulary and MedDRA conventions, side effects are "very common" when they occur in more than 1 in 10 instances