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As in other hemolytic anemias, patients with PKD can develop lowerextremity ulcers, usually medial in association with the medial malleolus, 29 which can be slow to heal or even fail to heal (Figure 2)

In addition, rather than scavenging radicals with antioxidants, the development of drugs activating ferroptosis defense regulators, such as GPX4 and FSP1, can be considered as a strategy for pharmacological approach for ferroptosis prevention

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