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This neuroimmune-tumor connection is also paradoxical as links also exists between chronic inflammation and tumorigenesis, with glioma cells producing pro-inflammatory cytokines, chemokines, and growth factors that create an inflammation-enriched TME (65, 66)

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Pathogenesis of diabetes is then characterized by a potent oxidative stress, as increased levels of reactive oxygen species (ROS) are present (194)

After overnight incubation, flow cytometry revealed pSTAT5 activation in CD4, CD8, and CD56 cells only upon MMP7 treatment (Fig