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7,8 Alterations in DNA damage-response pathways have been further associated with immune deficiency, infertility, premature aging and the development of atherosclerosis

Nevertheless, formal demonstration of causality awaits the following functional rescue experiments, including ferroptosis inhibitor (Fer-1) or inducer (Erastin) intervention to verify that TSWN protection is truly ferroptosis-dependent and in vitro AMPK knock-down or dominant-negative mutation to confirm that GPX4 up-regulation is AMPK-dependent

The combination of insulin-like growth factor I and insulin-like growth factor-binding protein-3 reduces insulin requirements in insulin-dependent type 1 diabetes: evidence for in vivo biological activity

It also demonstrated cerebroprotective effects comparable to those of edaravone in a rat model of cerebral ischemia/reperfusion injury (Fukuta et al., 2023)