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Approximately 60% of an absorbed Cr(VI) dose is excreted predominantly in the form of Cr(III) via the renal system within 8 h of ingestion

We compared our candidate drugs to known anti-melanoma and NO-based drugs using publicly available drugs screens and high-throughput CRISPR data and experimentally validated six of these candidates in BRAF and NRAS mutated cell lines in mono and combination treatment with BRAF/MEK inhibitors

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These NPs, with sizes ranging from 200 to 300 nm and a surface charge of 20 to 30 mV, demonstrated increased retention time on ocular tissues due to their mucoadhesive properties