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Vitamin B12 supplements are generally considered safe

While very high oral doses (1,000 to 2,000 mcg) can achieve some passive absorption without intrinsic factor roughly 1% of the dose is absorbed passively many clinicians prefer the reliability and rapid correction offered by injections in this population

When are B12 injections used

Supporting this, in a phase 2a trial in people with MASLD, the dual GLP-1/GCG agonist efinopegdutide (10 mg) reduced liver fat by 72.7%, compared to 42.3% with semaglutide (1 mg) despite similar WLindicating potential weight-independent effects of GCG on hepatic steatosis [40]