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Efficacy was further assessed in mouse and rat macrophages and duodenal biopsies from CD patients, as well as in C57BL/6J mice and the transgenic DQ8-D d -villin-IL-15tg model, with a focus on its capacity to prevent hallmark CD features, including villous atrophy, disease-specific Abs, and other biomarkers

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Yamaguchi S, Franczyk MP, Chondronikola M, Qi N, Gunawardana SC, Stromsdorfer KL, Porter LC, Wozniak DF, Sasaki Y, Rensing N, Wong M, Piston DW, Klein S, Yoshino J

Based on the phase 2 and phase 3 trial protocols: Weeks 1-4: 1 mg once weekly Weeks 5-8: 2 mg once weekly Weeks 9-12: 4 mg once weekly Weeks 13-16: 8 mg once weekly Weeks 17 onward: 12 mg once weekly (maximum dose) The starting dose of retatrutide is deliberately low because the triple-agonist mechanism produces more intense initial side effects than single-pathway compounds