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In hypercholesterolemic mice, deletion of Arg2 or inhibition of arginase with BEC improves endothelial function and reduces atherosclerosis (Ryoo et al., 2008)

A post-hoc subgroup analysis of that trial suggested benefit of prasinezumab in subjects with faster progression [209] and a comparison of MDS-UPDRS progression during the 4-year open-label extension phase with historical controls showed divergent trajectories in favour of prasinezumab from year 2 of treatment onwards [210]

Disturbances in iron metabolism are typical of subarachnoid hemorrhage (ASH), and in the treatment of ASH with oncostatin M (OSM, an iron-regulator inducer) it was found that the expression of hepcidin was increased and the expression level of Fpn1 was decreased by the action of OSM, enhancing the sensitivity to ferroptosis [35]

By enabling timely risk assessment, AI-driven predictive models can guide preventive strategies, minimizing the risk of complications and improving long-term patient outcomes