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Proteinligand nteractions (hydrogen bonds, hydrophobic, onic, and water bridges) graph This graph displays the various types of interactions (hydrogen bonds, hydrophobic nteractions, onic nteractions, and water bridges) between MEL and the MT1 and MT2 receptors over time (Fig

Histopathological analysis revealed loss and degeneration of hippocampal CA2 neurons after 120180 days, which was not observed in other brain regions

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7.2 Signaling pathway driven-activation (polarization) of central glial cells Mitogen-activated protein kinases (MAPK) signaling pathway: Activation of central glial cells is primarily characterized by morphological changes, upregulation of classical activation markers, expansion of cell populations, and enhanced pro-inflammatory responses