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Description

ROS attack macromolecules within the neuronal plasma membrane which leads to their oxidative modification and destruction (Subramaniam and Chesselet, 2013)

In a study utilizing a neonatal mouse model of hypoxicischemic brain injury, it was demonstrated that hydrogen activates the Nrf2 pathway to enhance intracellular antioxidant defenses, effectively clearing excess ROS

[DOI] [PMC free article] [PubMed] [Google Scholar] 149.Chen Q., Espey M.G., Sun A.Y., Pooput C., Kirk K.L., Krishna M.C., Khosh D.B., Drisko J., Levine M