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FIGURE 1 5 Multiple cell ferroptosis promotes atherosclerosis 5.1 Ferroptosis of vascular endothelial cells promotes atherosclerosis AS begins with vascular endothelial dysfunction, characterized by increased permeability, leukocyte adhesion, heightened inflammation, and accelerated plaque and thrombus formation

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It will also explain why it is likely that, in certain tumors, mutations producing these neomorphic alleles are early events, emphasizing the importance of targeting these driver mutations