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Overall, these findings lend support to the notion that reversible and bulkier cyclohexenone-based warheads may be well-suited to sense subtle structural differences around the targeted nucleophile, and thus they may also contribute to isoform specificity on their own right in TCIs

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DiNicolantonio explains: 18 "With respect to carnitine and CV risk, a meta-analysis 19 of prospective clinical trials in patients who had recently experienced a myocardial infarction concluded that carnitine supplementation is markedly protective with respect to total mortality, ventricular arrhythmias and new-onset angina Clinical trials 20, 21 have also reported favorable effects of supplemental carnitine or carnitine esters on angina, intermittent claudication and heart failure