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Bentov Y, Esfandiari N, Burstein E, Casper RF

Biased computation of probability of target attainment for antimicrobial drugs

indicated that endoplasmic reticulum stress kinase PERK (EIF2AK3) is a receptor for TMAO

In bypass, pyruvate is first converted to ACH by pyruvate decarboxylase (Pdc) and then ACH is metabolized either to acetate by aldehyde dehydrogenases (Ald) or turned into ethanol by alcohol dehydrogenase (Adh) enzymes