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Ethics approval and consent to participate This study was carried out and approved by the Animal Ethics Committee of the Faculty of Veterinary Medicine at Suez Canal University approved the study design (2019035)

(1999) Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency

Mitochondrial dysfunction: NRF2 also orchestrates mitochondrial proteins such as superoxide mutase 1 (SOD1), which scavenges mitochondrial ROS and RNS to protect the mitochondrial respiratory chain from oxidative insults (Gumeni et al., 2021) and protein deglycase DJ-1 (PARK7), which maintains mitochondrial complex I activity and the mitochondrial membrane potential, two critical indicators for mitochondrial health (Hayashi et al., 2009