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10.1038/s42003-025-07738-0 21 LeaM.NourE.HilaD.ZaitY.ScharffY.Ben-YosefS.et al (2022)

Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization

TP73 increases by 938%, while USP29 (which stabilizes p53) increases by 1,056%

That distinction matters for people who want to look refreshed while still letting their face communicate joy, concern, surprise, and warmth