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(2021) demonstrated that exposure to simulated microgravity for a duration of 3 weeks resulted in impairment of the intestinal mucosal barrier, characterized by reduced goblet cell count, enlarged intercellular space, downregulated adhesion molecules, and increased intestinal permeability in rats

These findings suggest that the BsmI polymorphism has an important regulatory role in T2DM-related osteoporosis and may serve as a potential diagnostic marker for T2DM-related osteoporosis