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Conclusion This review distinctively highlighted the in vitro, in vivo, and clinical studies conducted on the neuroprotective potential of natural compounds in Parkinsons disease (PD), discussing the various models of PD used, specified concentrations or doses of natural compounds, and the mechanism of their actions

Human umbilical vein endothelial cells (HUVECs) in culture showed significant increases in the activities of GR, GPx, GST, NQO-1, SOD, and CAT when treated with 50 M genistein (104) ( Supplementary Table 1 )

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Moreover, lower ceramide levels improved mitochondrial phenotypes in PINK1-mutant flies and PINK1-deficient patient-derived fibroblasts (Vos and Klein, 2022)