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Published online April 23, 2013

doi: 10.1126/science.aaa1348 7 BrahmerJRTykodiSSChowLQHwuWJTopalianSLHwuPet al

If you have been titrating up through 2.5mg, 5mg, 7.5mg, 10mg, and 12.5mg, you already know that each dose escalation brings its own adjustment period