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Betzel, Alessandra Griffa, Patric Hagmann, and Bratislav Mii

ASD phenotypes (social-communication impairments and restricted, repetitive patterns of behavior) are commonly associated with intellectual disabilities, anxiety, depression, epilepsy, attention deficit hyperactivity disorder (ADHD), sleep disorders, dyspraxia, and lack of verbal communication [40]

While direct evidence from silicosis models is still needed, this mechanistic insight suggests that targeting ferroptosis via stem cell paracrine signaling could represent a promising therapeutic approach against silica-induced pulmonary fibrosis

However, some overlap exists, as an increase in TREM2, APOE, MHC-II, HLA-DRA, and CD68 genes are shown in humans and 5xFAD mice