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doi: 10.1016/j.actbio.2019.03.021 122 NakaoYFukudaTZhangQSanuiTShinjoTKouXet al

229 A meta-analysis of 35 observational studies found that older adults with hearing loss had 47% greater odds of depression

The targeted delivery of intracellular copper relies on multiple metallochaperone systems:(a) Cytochrome c oxidase copper chaperone COX17 (Cox17) transports copper to mitochondria and participates in cytochrome c oxidase assembly (Amaravadi et al., 1997)