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Description

Excessive ROS can overwhelm the endogenous antioxidant defense system, leading to oxidative damage, including lipid peroxidation reflected by elevated MDA levels [55-57]

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APIT may not be suitable for individuals with certain allergies, especially if related to the injectable substances

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Concurrently, elevated pyruvate kinase M2 (PKM2) expression upregulates Bcl-xL [59], while mesenteric adipose tissue (MAT) and lamina propria lymphocytes (LPL) show characteristic apoptotic dysregulation with increased Bcl-2 and decreased BAX expression [60, 61]

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J Immunol 127: 22572262

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