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Research in aged primates demonstrates that Epithalon administration significantly increases nighttime melatonin levels in senescent monkeys while showing minimal effects in young animals, indicating specific targeting of age-related dysfunction

The main therapy was by control of predisposing factors of DM (11), hyperlipidemia (10), and obesity (3 patients had lean body NASH)

Blockade of lactate dehydrogenase-a (Ldh-a) improves efficacy of anti-programmed cell death-1 (Pd-1) therapy in melanoma

BSO treatment decreases GSH levels in whole cells as well as in purified mitochondria with similar kinetics 14 (Fig.1a)