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These proteins are associated with various functions, including DNA repair, regulation of metabolism and body weight, and maintenance of mitochondrial health

A population-based study in 3,884 elderly men and women with depressive disorders found that those with vitamin B 12 deficiency were almost 70% more likely to experience depression than those with normal vitamin B 12 status (98)

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Vitamin B 12 deficiency, like folate deficiency, may lead to decreased synthesis of methionine and S-adenosylmethionine (SAM), thereby adversely affecting methylation reactions