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ROS-induced HIF-1 stabilisation leads to the activation of macrophages in the early stages of wound healing, and promotes metabolic reprogramming towards glycolysis 75,76 , as well as increased angiogenesis 76

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It was found that immune-activated CD8 + T cells secreted interferon (IFN) that downregulated the expression of SLC7A11 and SLC3A2 expression (Wang W et al., 2019)