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BPC-157 equaled or exceeded imipramine (a standard tricyclic antidepressant) in forced swimming tests, the gold-standard animal model of antidepressant action

Strikingly, the CREB inhibitor 666-15 as well as another small molecule, the PI3K/AKT inhibitor GSK690693, attenuated chemoresistance in the cancer cells with ZIP10 overexpression

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In a report published Wednesday in the New England Journal of Medicine, researchers with Pfizer and the University of Texas Medical Branch created a version of the virus that carried the same mutations found in the South African variant dubbed B.1.35.1