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At baseline levels, ROS support normal cellular functions, but when in excess, they can damage macromolecules such as lipids, DNA, and proteins (Sies, 2018), triggering cellular senescence

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269 BCAA uptake is dependent on the type I amino acid transporter LAT, and mutations in SLC7A5 and SLC3A2, members of the LAT family, impair BCAA uptake by T cells and inhibit the proliferation and differentiation of Th1, Th17, and CTL cells