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Description

Formation of intracellular aggregates of various crystallin proteins was visualized by fluorescence of GFP (green) and the nuclei were stained with Hoechst 33342 (blue)

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As a new uremic toxin and potential biomarker, TMAO is involved in changes in the heart-gut-kidney axis, including neuroendocrine activation, hemodynamic changes, alterations in gut microbiota, and intestinal congestion (Xiong et al., 2023)

This rate-limiting step is catalyzed by glutamate-cysteine ligase (GCL) a heterodimeric enzyme composed of a catalytic subunit encoded by GCLC and a modifier subunit encoded by GCLM