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Baldelli S, Ciccarone F, Limongi D, Checconi P, Palamara AT, Ciriolo MR

Oxidative stress impairs SIRT3 activity and transcription by regulating protein carbonylation and transcriptional function of peroxisome proliferator-activated receptor- coactivator-1, leading to mitochondrial dysfunction and activation of the mitochondrial apoptotic pathway via optic atrophy 1 to induce cell death of vitiligo melanocytes [32]

Similarly, vitamin D supplementation, although safe at recommended doses, can lead to hypercalcemia and hypercalciuria if administered in excess [151]

A GSHS-like gene from Lycium chinense maybe regulated by cadmium-induced endogenous salicylic acid and overexpression of this gene enhances tolerance to cadmium stress in Arabidopsis