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With respect to epigenetic regulation, CTBP functions as a transcriptional repressor by associating with nucleosome remodeling and the deacetylase (NURD) complex 148 , class II HDACs (HDAC4/5/7/9) 178 , and COREST (co-repressor of REST), which includes HDAC1/2 and LSD1, and removes acetyl groups and H3K4 monomethylation/dimethylation from nucleosomes, leading to transcriptional repression 179 (Fig

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For these six subjects, baseline GSH levels were all assigned the same value (the lowest measured GSH/Cr ratio value across all subjects and scans, divided by 2), in order to calculate the absolute change in GSH/Cr ratio relative to baseline

Funding This research was supported by Luzhou's major scientific and technology research and development project (nos.2022-SYF-42), Luzhou Municipal People's GovernmentSouthwest Medical University Science and Technology Strategic Cooperation Climbing Plan Project, (2021LZXNYD-D02), Joint Innovation Special of the Sichuan Provincial Science and Technology Plan (nos.2022YFS0609/2022YFS0609-B3), the Sichuan Science and Technology Department Project Development Project(nos