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* Correspondence: Fang Li, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Elevated levels of ROS, free mtDNA, and inflammatory factors in the follicular fluid during ovarian aging [312,313,314], indicate that mitochondria-driven inflammation may be closely associated with age-related decline in fertility [315]

Risk factors include exceeding recommended doses (often unintentionally due to acetaminophen being in many combination products), chronic heavy alcohol use, poor nutrition, and existing liver disease