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Whether or not objective criteria are eventually useful in diagnosing RLS depends on how well-understood the patient's symptoms are and how forthcoming the patient is with the researcher, as the sensations are subjective to the patient

This is particularly important in neurodegenerative diseases where oxidative stress is a contributing factor

10.1177/1352458514533400 17 CarveyP

However, the metabolites in the GSH synthesis, export and reimport pathway decline very slowly, achieving their new steady states in 45 days (data not shown)