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[163, 165] have reported that off-target toxicity in peripheral organs remained minimal, although they emphasised that excessively high doses or positively charged CQDs may still provoke ROS formation, mitochondrial dysfunction, or the activation of inflammatory pathways [163, 165]

FIGURE 3 5.1 In vitro immunomodulating effect of Zingiber officinale An in vitro effect of several herbal products on transplant-related immune function in mixed lymphocyte culture demonstrated that ginger inhibited lymphocyte proliferation via the reduction of the IL-2 level (Wilasrusmee et al., 2002)

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Pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) expressed on epithelial cells interact with microbiota-derived pathogen-associated-molecular patterns (PAMPs) such as lipopolysaccharide (LPS) to activate myeloid differentiation factor 88 (MYD88)-dependent signaling